May 8, 2020
草莓污视频导航 researchers develop a new method to test for COVID-19
A research team led by scientists at the 草莓污视频导航鈥檚 (CSM) is sharing a new method to test for SARS-CoV-2, the virus that causes COVID-19. The test can provide results in 30 minutes without the need for high-tech equipment and the reagents that have been in limited supply worldwide.
鈥淩esults from this method can be seen with the naked eye, the chemicals required are easier to access, and do not require refrigeration,鈥 says Dr. Dylan Pillai, MD, PhD, study lead, clinical-researcher and member of the and the at the CSM. 鈥淭he process can be made portable, which opens up testing in resource-limited settings.鈥
- Photo above:听Researchers Dylan Pillai (standing) and Abu Naser Mohon in the lab at the Snyder Institute. Photo by Riley Brandt, 草莓污视频导航
Further research and validation is ongoing to evaluate the possibilities for large-scale testing using this method, and to determine when the test may be available for widespread use in Canada and around the world.听
鈥淲e are in the early stages of unlocking the potential of this method,鈥 says Dr. Byron Berenger, MD, co-author,
(APL) Public Health Laboratory. 鈥淎s we鈥檝e seen in Alberta, detecting and tracking positive cases of COVID-19 has proven critical in containing the spread of the virus.鈥
The process uses a technique called loop mediated amplification (LAMP) which detects the viral genetic material from a nasopharyngeal (nose/throat) swab or saliva. LAMP does not require expensive laboratory equipment and the result can be seen without instrumentation.听
鈥淲e鈥檝e taken the lessons from our extensive work with LAMP for malaria in and applied them to a testing method for SARS-CoV-2,鈥 says study first author, Dr. Abu Naser Mohon, PhD, a member of the Pillai Lab.
The research team also includes experts from and the , in Seattle. on a free online health sciences server, , so that laboratories across the globe can benefit. In parallel, the team has submitted the study to a peer-reviewed journal for input from noted experts in the fields of infectious disease, and microbiology.
鈥淲e鈥檙e in the midst of a pandemic. We鈥檝e validated the process and found that the test shows greater than 97 per cent accuracy compared to other molecular methods. It鈥檚 very important to get this information out so others can benefit,鈥 says Pillai. 鈥淎ny clinical laboratory can adopt this method into its workflow now. We know for some places in the world, testing large numbers of people is difficult 鈥斕齮his simplifies the process and makes it accessible.鈥
The research is supported by the (CIHR), and the 草莓污视频导航/Alberta Health Services Clinical Research Fund. The grants were announced the first week in March.
The research team says the work is not over. While no high-tech equipment is needed for the testing method, it still requires small laboratory items. The team is now working to develop a hand-held cartridge test which could be used anywhere and would not require any additional lab items. The researchers hope to have a working model before the end of the year.
Pillai Lab
Dylan Pillai is a professor in the departments of , , and and member of the Snyder Institute for Chronic Diseases and the Alberta Children鈥檚 Hospital Research Institute at the CSM.
Infections, Inflammation and Chronic Diseases
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