Cellular, Molecular and Microbial Biology CMMB

CMMB 343 403 411 413 421 431 443 451 461 505 507 511 519 523 527 528 530 531 543 545 549 561 563 565 567 637

Instruction offered by members of the Department of Biological Sciences in the Faculty of Science.

Department Head 鈥� R.M.R. Barclay

鈥灿辞迟别: Limited amounts of non-scheduled class time involvement will be required for this course.

Senior Courses

鈥燙ellular, Molecular and Microbial Biology 343

Microbiology

An introductory study of prokaryotes, viruses and immunology with emphasis on systematics, ecology, physiology, molecular biology and roles in pathogenesis of the major groups of prokaryotes.
Course Hours: 3 units; H(3-3)
Prerequisite(s): Chemistry 351 and one of Biology 231 or 243 or 311 or Medical Science 341.
Notes: Prior completion of or concurrent registration in Biochemistry 393 and Chemistry 353 is strongly recommended.

Cellular, Molecular and Microbial Biology 403

Developmental Biology of Animals

Study of the mechanism of cellular differentiation with emphasis on intra- and intercellular processes.
Course Hours: 3 units; H(3-1T)
Prerequisite(s): Biochemistry 393; and one of Biology 311 or Medical Science 341; plus one of Biology 331 or Medical Science 351.
Notes: Enrolment in this course may be limited. See Enrolment Limitations in Courses in the Faculty of Science section of the Calendar.

Cellular, Molecular and Microbial Biology 411

Molecular Genetics

Molecular biology and gene expression in prokaryotes and eukaryotes. Topics include: DNA topology, genome structure, chromatin structure, DNA replication, DNA repair and recombination, mechanisms of transcription and gene expression, post-transcriptional RNA processing, translation.
Course Hours: 3 units; H(3-0)
Prerequisite(s): One of Biology 311 or Medical Science 341; and one of Biology 331 or Medical Science 351.
Notes: Prior completion of or concurrent registration in Biochemistry 401 or 443 is strongly recommended.

Cellular, Molecular and Microbial Biology 413

Human Genetics

The principles of genetics as applied to human and medical genetics. Mendelian and multifactorial inheritance of normal and abnormal traits, pedigree analysis, segregation, linkage and gene mapping. Cytogenetics and developmental genetics. Population genetics including inbreeding and evolution in humans. Genetic predisposition to disease.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Biology 311 or Medical Science 341.

Cellular, Molecular and Microbial Biology 421

Virology

Comprehensive overview of virus structure and replication; molecular events involved in virus infection and replication including genetics, biochemistry and molecular biology of bacterial, plant and animal viruses. Areas of persistent viruses, viral immunology, cancer and AIDS will be covered.
Course Hours: 3 units; H(3-2T)
Prerequisite(s): Biochemistry 393 and Cellular, Molecular and Microbial Biology 343; and one of Biology 311 or Medical Science 341; as well as one of Biology 331 or Medical Science 351.
Notes: Enrolment in this course may be limited. See Program Details in the Faculty of Science section of this Calendar. Prior completion of or concurrent registration in Biochemistry 401 or 443 is strongly recommended. 聽聽聽聽聽聽聽聽聽聽

Cellular, Molecular and Microbial Biology 431

Bacterial Pathogens

An introduction to microbes that cause infections (in humans, other animals and plants.) Topics include: the relationship between pathogen and host, ability of pathogens to colonize, reproduce and cause disease, the role of antibiotics and vaccines in treatment and prevention of infection, antibiotic resistance in bacteria, environmental control of virulence factor production.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 343.

Cellular, Molecular and Microbial Biology 443

Microbial Physiology

The focus is structure and function of prokaryotic cells. Topics include cell envelope structure, cell division, transport and secretion, signal transduction, differentiation and development, bacterial growth and energetics, and the diversity of metabolic pathways in Bacteria and Archaea. The laboratory introduces analytical techniques commonly used in bacterial physiology, and some useful biochemical assays.
Course Hours: 3 units; H(3-3)
Prerequisite(s): Biochemistry 393 and Cellular, Molecular and Microbial Biology 343.
Notes: Enrolment in this course may be limited. See Program Details in the Faculty of Science section of this Calendar.

Cellular, Molecular and Microbial Biology 451

Molecular Analysis of Biological Systems

A laboratory course emphasizing techniques in molecular biology that can be applied to the analysis of problems in cellular, molecular and microbial biology.
Course Hours: 3 units; H(3-5)
Prerequisite(s): Cellular, Molecular and Microbial Biology 411.
Antirequisite(s): Credit for both Cellular, Molecular and Microbial Biology 451 and either Biochemistry 401 or 541 will not be allowed.
Notes: Only open to Majors in Cellular, Molecular and Microbial Biology or to Majors in the Biological Sciences Honours program.

Cellular, Molecular and Microbial Biology 461

Functional Genomics and Molecular Networks

Introduction to high-throughput methods for global functional and network analysis of genes and proteins. Topics include microarrays, chromatin immunoprecipitation, synthetic genetic array analysis, next-generation sequencing and network topology.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Biology 331.
Also known as: (formerly Biology 461)

Cellular, Molecular and Microbial Biology 505

Advanced Developmental Biology

In-depth analyses of the current literature in developmental biology. Emphasis will be on the co-ordinated regulation of gene expression during development.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 403.

Cellular, Molecular and Microbial Biology 507

Special Problems in Cellular, Molecular and Microbial Biology

Independent Research or reading project that may include seminars, lectures, term papers and training in theoretical and/or laboratory methods.
Course Hours: 3 units; H(0-8) or H(3-0)
Prerequisite(s): Completion of at least 54 units (9.0 full-course equivalents) and consent of the Department.
MAY BE REPEATED FOR CREDIT

Cellular, Molecular and Microbial Biology 511

Molecular Biology and Genetics

The concepts of molecular biology as they apply to genetics. Application of current methodology to the understanding of the genetics of prokaryotes, lower and higher eukaryotes (for example: fungi, yeasts, trypanosomes, plants and animals). Genomic organization and function of subcellular organelles such as mitochondria and chloroplasts will also be considered in detail. The mechanism(s) of regulation of gene expression will be discussed in relation to nuclear as well as organelle genomes.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 411.

Cellular, Molecular and Microbial Biology 519

Advanced Cell Biology

In-depth analysis of current literature in cell biology. Topics include subcellular organization and dynamics, cell signalling and differentiation, protein and RNA trafficking, and other aspects of eukaryotic cell biology.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Biology 311 and 331 and one of Biochemistry 401 or 443.

Cellular, Molecular and Microbial Biology 523

DNA Genomes and RNA Function

An examination of information storage and gene expression in prokaryotes and eukaryotes. Biochemical mechanisms of gene expression and regulation in bacteria. Genome sequencing projects and a survey of genome structure and content across domains of life. Topics in eukaryotic gene expression. The diverse roles played by RNA, from information molecules to structural scaffolds to ribozymes.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 411.

Cellular, Molecular and Microbial Biology 527

Immunology

Comprehensive overview of the immune system and how immune responses are generated and regulated in the context of infectious diseases. Topics include both fundamental cellular and molecular immunology. Dysregulated responses, such as autoimmunity, immunodeficiencies, transplants, and allergies will also be covered.
Course Hours: 3 units; H(3-3)
Prerequisite(s): Biology 311 and 331 and Cellular, Molecular and Microbial Biology 343 and one of Biochemistry 401 or 443.
Notes: Enrolment in this course may be limited. See Program Details in the Faculty of Science section of this Calendar.

Cellular, Molecular and Microbial Biology 528

Independent Studies in Cellular, Molecular and Microbial Biology

Original and independent thought, practical research and the completion of written and oral reports.
Course Hours: 6 units; F(0-8)
Prerequisite(s): Completion of at least 90 units (15 full-course equivalents) and consent of the Department.
MAY BE REPEATED FOR CREDIT

Cellular, Molecular and Microbial Biology 530

Honours Research Project in Cellular, Molecular and Microbial Biology

Research project under the direction of one or more faculty members in the Department of Biological Sciences. Formal written and oral reports must be presented on completion of this course. Open only to Honours Cellular, Molecular and Microbial Biology students or Honours Biological Sciences students.
Course Hours: 6 units; F(0-8)
Prerequisite(s): Cellular, Molecular and Microbial Biology 451 and completion of at least 90 units (15 full-course equivalents) and consent of the Department.

Cellular, Molecular and Microbial Biology 531

Topics in Cellular Interactions

An exploration of selected topics concerning cell-cell interactions and the interactions of cells with their environment during development, differentiation and disease (cancer). Multidisciplinary approaches will be presented, using discussions of seminal research and critical analysis of current literature. Potential topics include cell junctions, cell signaling, cytoskeletal organization, stroma, extracellular matrix remodelling and stem cells and cancer stem cells.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Biology 331 and one of Biochemistry 401 or 443 or 431.

Cellular, Molecular and Microbial Biology 543

Environmental Microbiology

Focuses on understanding the interactions of micro-organisms with their environment. Roles of micro-organisms in nutrient cycling, biological control, and biodegradation will be discussed. The use of molecular approaches to identify and characterize microbial communities, and to understand the precise nature of microbial interactions with abiotic and biotic environments will be emphasized. Special topics will include plant-microbe and animal-microbe symbiosis, extreme environments and biotechnological applications of environmental microbiology.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 343.

Cellular, Molecular and Microbial Biology 545

Petroleum Microbiology

Microorganisms can contribute to a more sustainable energy future. Their impact and roles in the fossil fuel industry will be reviewed. Topics will include oilfield souring, biocorrosion, biodegradation, enhanced recovery, upgrading, and bioremediation of contaminated sites.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 343.

Cellular, Molecular and Microbial Biology 549

Microbial Genetics

The genetics and genomics of prokaryotes. Topics will include recombination, mechanisms of genetic exchange, analysis of genes and genomes, and genome evolution. Selected current topics in bacterial genetics will also be covered.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 411.

Cellular, Molecular and Microbial Biology 561

Cancer Biology

Advances in methodology and in theoretical concepts have permitted continuing breakthroughs in our understanding of the organismal, cellular and molecular biology of cancer cells, and in the development of novel strategies for cancer prevention, diagnosis and treatment. These advances will be presented in a comprehensive overview of cancer including issues of demographics and incidence, causation and detection, origins and progression and therapeutic approaches. Emphasis will be placed on the cell and molecular biology of cancer and on the interaction of the cancer cell with the host organism.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Biology 331 and Cellular, Molecular and Microbial Biology 411 and one of Biochemistry 401 or 443.
Also known as: (Medical Science 561)

Cellular, Molecular and Microbial Biology 563

Microbial Diversity

An overview of microbial diversity, the evolutionary mechanisms that give rise to it, and the methods used to study it. Topics may include: microbial systematics; characterizing the last universal common ancestor of life; estimating global microbial diversity; 鈥渦nculturable鈥� microbes and molecular DNA-based methods used to study them in nature; modern cultivation techniques; comparative genomics of microbial species; environmental metagenomics; microbial biogeography and speciation and gene flow in microbial communities.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 343.

Cellular, Molecular and Microbial Biology 565

Advanced Topics In Pathogenic Microbiology

Provides a fuller understanding of bacterial diseases using a systems approach and illustrating key paradigms via the consideration of specific pathogens. Topics include: strategies for bacteria surviving host immune responses, bacterial invasion strategies, opportunistic infections, disease Pathogenesis, and antibiotic resistance, challenges of dealing with emerging infections. Lectures, small group interactive sessions, specified readings.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 343 and 431.
Also known as: (Medical Science 565)

Cellular, Molecular and Microbial Biology 567

Advanced Topics In Immunology

New and emerging themes in immunology, with an emphasis on disease processes such as inflammation in the gut, kidney and lung. Topics include: innate immunity, the inflammasome, sterile inflammation, process and mechanism of immune cell recruitment in different tissues, T cell biology, B cell biology, regulatory immune cells, mucosal immunity, airways responses to virus, mechanisms of food allergies, inflammatory bowel disease. Lectures, small group interactive sessions, specified readings.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 527.
Also known as: (Medical Science 567)

Graduate Course

Enrolment in any graduate course requires consent of the Department.

Only where appropriate to a student's program may graduate credit be received for courses numbered 500-599.

600-level courses are available with permission to undergraduate students in the final year of their programs.

Cellular, Molecular and Microbial Biology 637

Advanced Topics in Molecular Microbiology

Techniques and discussion of recent literature in molecular microbiology. Topics covered will vary from year to year, but could include bioinformatics, genomics, mutagenesis, advanced microscopy techniques, proteomics, vectors and cloning techniques, gene expression, and over-expression of proteins, as they relate to the study of prokaryotic systems. Course content will be tailored to the interests of the graduate students enrolled in the class in a given year.
Course Hours: 3 units; H(3-0)

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